Western Diet Impairs Memory in Rats Can It Do So in Humans? Summary: A study published in Brain, Behavior, and Immunity investigated how early-life exposure to a Western-style diet affects memory and brain function. The research, conducted by Hayes et al. (2024), focused on the long-term cognitive consequences of consuming highly processed, high-fat, high-sugar foods during development. Study design Male Sprague Dawley rats were assigned to either a Western-style “ junk food ” diet (20% protein, 35% carbohydrates, 45% fat) or a healthy control diet starting on postnatal day 26. Western-diet exposure lasted 30–60 days , after which all rats were transitioned to a healthy diet. Food intake, behavior, memory performance, metabolic outcomes, brain neurochemistry, and gut microbiome composition were assessed. Key findings Increased caloric intake: Rats fed the Western diet consumed 15% more calories than controls. Selective memory impairment: Western diet–expose...