Gut Microbiome, Loneliness, and Wisdom: A Nutritional Psychology Perspective Loneliness has consistently been linked to poorer well-being, while wisdom appears to promote emotional resilience and life satisfaction. Beyond psychological outcomes, loneliness has also been associated with changes in cardiovascular, neuroendocrine, and immune functioning, including activation of pathways within the microbiota–gut–brain axis, particularly the hypothalamic–pituitary–adrenal axis. Building on this foundation, the present study explored whether the gut microbiome is associated with loneliness, wisdom, or both. Study Design The study included 184 community-dwelling adults aged 28 to 97 years. Participants completed questionnaires measuring loneliness, wisdom, compassion, social support, and social engagement. Fecal samples were collected and analyzed using 16S rRNA sequencing to assess gut microbial diversity. Two types of microbial diversity were examined: Alpha diversity , which...